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KMID : 0350519920450041501
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Journal of Catholic Medical College
1992 Volume.45 No. 4 p.1501 ~ p.1514
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Effects of Fluid Intake, Dietary Fiber Supplement and Abdominal Muscle Exercises on Antipsychotic Drug-Induced Constipation in Schizophrenics
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양수lk
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Abstract
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This study was designed and undertaken to search for the most appropriate methods in nursing domain of relieving and preventing constipation induced by antipsychotic drugs that lead to physical discomfort in schizophrenic patients. For this
purpose
interviews and questionnairs were employed and observational and biological data of patients were collected. The study was carried out with a non-equivalent pre-test/post-test design.
The fifty-six schizophrenic inpatients(male; 28, female; 28) by the Diagnostic and Statistical Manual of Mental Disorders-III-R(American Psychiatry Association. 1987) were sampled from two college hospitals and one private mental hospital from
February
24th, 1992. They were randomly divided into three groups: a control group of 20, experimental group 1 of 18 and experimental group 2 of 18 individuals. All of the subjects was revealed to have antipsychotic drug-induced constipation during the
first
two-weeks of control period.
All of the patients had started with a control period of two and had an experimental period o f four weeks afterwards. The two experimental groups were equally given daily 1500ml of fluid in addition to their normal fluid intake and they
performed
exercises more than fifteen minutes a day to strengthen abdominal muscles. Patients in experimental group 2 were also given daily 10g of alpha-cellulose and 5g of citrus pectins. Absorption levels of minerals of K, Ca, Mg and of haloperidol were
measured in serum samples.
The data were analyzed by the statistical methods of Multiple Regression, ANOVA, and Repeated Measures ANOVA and Scheffe test.
@ES 1, The results related to the number of constipated days were as follws:
@EN a. In control group the average number of constipated days per week was increasing over time, with a statistically significant difference from the third week onwards after treatment(F=5.43, P=0.0323; F=4.55, P=0.0463).
b. In experimental group 2 the average number of constipated days per week was decreasing over time, with a statistically significant difference from the second week onwards after treatment (F=8.37, P=0.0101; F=6.47, P=0.0210; F=13.18,
P=0.0021).
c. The average number of constipated days per week was significantly different among three groups, experimental group 2 having significantly shorter days than control group in the first week after treatment(F=5.77, P=0.0054). Control group had
significantly longer days than experimental group 1 and 2 from the second week onwards after treatment(F=16.53, P=0.0001; F=20.46, P=0.0001; F=25.37, P=0.0001).
d. The number of constipated days was determined by the following variables: the number of constipated days before treatment, the amount of fluid intake before treatment and the number of employed experimental treatments.
2. The results related to the severity of constipation were as follows:
a. In control group the severity of constipation was increasing over time, with a statistically significant difference form the third week onwards after treatment(F=13.77, P=0.0015; F=4.37, P=0.0503).
b. In experimental group 2 the severity of constipation was decreasing over time, with a statistically significant difference from the third week onwards after treatment(F=4.52, P=0.0485; F=11.76, P=0.0032).
c. The severity of constipation was significantly different among three groups, control group having significantly higher scores than experimental group 1 and 2 from the third week onwards after treatment(F=13.56, P=0.0001; F=10.41, P=0.0002).
d. The severty of constipation was determined by the following variables: the severity of constipation before treatment, the number of admission and the number of employed experimental treatments.
3. There was no difference in the serum levels of minerals and haloperidol among three groups.
In the light of these results, this study implies that fluid intake, dietary fiber supplement and increasing exercises for strengthening abdominal muscle is effective in relieving antipsychotic drug-induced constipation in schizophrenics. It was
noticed
that dietary fiber supplement did not inhibit absorption of minerals and drugs.
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